mitochondrial disorders การใช้

• Mitochondrial disorders often present themselves as neurological disorders, including autism.
• Jose suffers from mitochondrial disorder, which keeps his cells from developing and, ultimately, surviving.
• Mitochondria have been implicated in several human diseases, including mitochondrial disorders, cardiac dysfunction, heart failure and autism.
• It is likely that it is caused by a generalized cellular dysfunction caused by a mitochondrial disorder.
• Instead, the symptoms were caused by a mitochondrial disorder, an uncommon condition that is difficult to diagnose.
• The three most common neuro-ophthalmic abnormalities seen in mitochondrial disorders are bilateral optic neuropathy, ophthalmoplegia with ptosis, and pigmentary retinopathy.
• The government paid up, and its own experts found the link-a " possibly " preexisting mitochondrial disorder which can also be " acquired ".
• As such, mutations in these proteins can result in mitochondrial disorders, but can be inherited from both male and female parent in the typical fashion.
• With mitochondrial disorders caused by defects in the mtDNA, the severity of the disease depends on the number of mutant mtDNA molecules present in the cells.
• Mitochondrial disorders can appear in every generation of a family and can affect both males and females, but fathers do not pass mitochondrial traits to their children.
• However, he suffered muscle cramping during the game due to his mitochondrial disorder and had to be removed from the Rays'playoff roster, again putting his future playing career in doubt.
• During the 2008-09 offseason, further medical testing indicated that Baldelli suffers from a form of channelopathy, which makes his condition less serious and more treatable than the previous diagnosis of a mitochondrial disorder.
• Although many parents view this ruling as confirming that vaccines cause regressive autism, most children with autism do not seem to have mitochondrial disorders, and the case was conceded without proof of causation.
• However, mutations in BCS1L, a gene responsible for proper maturation of Complex III, can result in Bj鰎nstad syndrome and the GRACILE syndrome, which in neonates are lethal conditions that have multisystem and neurologic manifestations typifying severe mitochondrial disorders.
• Poling was diagnosed months later with encephalopathy ( brain disease ) caused by a mitochondrial enzyme deficit, a mitochondrial disorder; it is not unusual for children with such deficits to develop neurologic signs between their first and second years.
• There is little scientific research in the area : no scientific studies show whether childhood vaccines can cause or contribute to mitochondrial disease, and there is no scientific evidence that vaccinations damage the brains of children with mitochondrial disorders.
• Lactic acidosis in the context of mitochondrial disorders ( type B3 ) may be treated with a ketogenic diet and possibly with dichloroacetate ( DCA ), although this may be complicated by peripheral neuropathy and has a weak evidence base.
• Most of the body's cells contain thousands of mitochondria, each with one or more copies of mitochondrial DNA . The severity of some mitochondrial disorders is associated with the percentage of mitochondria in each cell that has a particular genetic change.
• Other disorders that may be accompanied by chorea include abetalipoproteinemia, ataxia-telangiectasia, biotin-thiamine-responsive basal ganglia disease, Fahr disease, familial dyskinesia-facial myokymia ( Bird-Raskind syndrome ) due to an ADCY5 gene mutation, glutaric aciduria, Lesch-Nyhan syndrome, mitochondrial disorders, Wilson disease, hyperthyroidism, lupus erythematosus, pregnancy ( chorea gravidarum ), and side effects of certain anticonvulsants or psychotropic agents.
• Although, the extended translocation of mtDNA fragments and their co-amplification with free mitochondrial DNA has been problematic in the diagnosis of mitochondrial disorders, in the study of population genetics, and phylogenetic analyses, scientists have used NUMTs as the genetic markers to figure out the relative rate of nuclear and mitochondrial mutation and recreating the evolutionary tree.